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Ic activity, nuclear pleomorphism, degree of cellularity, nuclear to cytoplasmic ratio, tumor size, mucosal invasion, ulceration, and tumor necrosis. Of these, both mitotic activity and tumor size are the most useful morphologic features in predicting malignant behavior. 1,2 tumor resection remains the primary treatment of all symptomatic gists and those suspected of being malignant or potentially malignant. Standard chemotherapy and radiotherapy have not been effective for patients with metastatic or unresectable gist. The use of imatinib(drug information on imatinib) mesylate may be effective for some patients with malignant gist. 1 join the conversation want to join the conversation?
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